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According to the label directions, zma should be taken 30 – 60 minutes. How long does zma take to work? How long does it take for a new blood pressure medication to work? all over his body. Many people is eyes flicked high blood pressure pills. Before you start using it, take time to research zma side effects and potential benefits. Are there side effects you should be aware of? How much magnesium bisglycinate should i take for sleep? Clearly, any climber engaging in serious strength training could benefit from taking this zma supplement (available from several different companies). Most over-the-counter drugs don't work, but i found one that does. And said i should take one half an hour before planning on sleeping. 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